J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 7, Number 2, February 2015, pages 91-96

Trends in the Epidemiological Aspects and Mortality of Alcoholic Liver Disease in Korea in the Decade Between 2000 and 2009

Figure 1. Trends in distribution rate (%) of the case-fatalities of the most prevalent types of alcoholic liver disease by ICD in Korea in the decade between 2000 and 2009.

**Table 1.** Comparisons of Trends in Alcohol-Consumption/Capita/Year (ACCY) in Korea in the Decade Between 2000 and 2009
Item	2000	2009	Changes rate (%)
Quant.: Quantity (unit: L). 95% CI: confidence interval of 95% of the rate. Statistically significant levels were set at P < 0.05 and *P < 0.01.
Makgeolli/takju	0.50 (5.9)	4.3 - 7.5	0.74 (8.7)	6.8 - 10.6	+2.8**
Soju	5.25 (62.7)	59.4 - 66.0	5.13 (60.1)	56.8 - 63.4	-2.6**
Cheongju	0.11 (1.3)	0.5 - 2.1	0.08 (0.9)	0.3 - 1.5	-0.4*
Beer	1.92 (22.9)	20.1 - 25.7	2.11 (24.7)	21.9 - 27.5	+1.8**
Wine	0.02 (0.3)	-	0.16 (1.8)	0.9 - 2.7	+1.5**
Spirits/whisky	0.44 (5.3)	3.8 - 6.8	0.25 (2.9)	1.8 - 4.0	-2.4**
Others	0.14 (1.7)	0.8 - 2.6	0.08 (0.9)	0.3 - 1.5	-0.8**
Total	8.38		8.54
P-value	< 0.01	< 0.01

Table 1. Comparisons of Trends in Alcohol-Consumption/Capita/Year (ACCY) in Korea in the Decade Between 2000 and 2009

Item

2000

2009

Changes rate (%)

Quant. (%)

95% CI

Quant. (%)

95% CI

Quant.: Quantity (unit: L). 95% CI: confidence interval of 95% of the rate. Statistically significant levels were set at *P < 0.05 and **P < 0.01.

Makgeolli/takju

0.50 (5.9)

4.3 - 7.5

0.74 (8.7)

6.8 - 10.6

+2.8**

Soju

5.25 (62.7)

59.4 - 66.0

5.13 (60.1)

56.8 - 63.4

-2.6**

Cheongju

0.11 (1.3)

0.5 - 2.1

0.08 (0.9)

0.3 - 1.5

-0.4*

Beer

1.92 (22.9)

20.1 - 25.7

2.11 (24.7)

21.9 - 27.5

+1.8**

Wine

0.02 (0.3)

0.16 (1.8)

0.9 - 2.7

+1.5**

Spirits/whisky

0.44 (5.3)

3.8 - 6.8

0.25 (2.9)

1.8 - 4.0

-2.4**

Others

0.14 (1.7)

0.8 - 2.6

0.08 (0.9)

0.3 - 1.5

-0.8**

Total

8.38

8.54

P-value

< 0.01

**Table 2.** Tends in the Mortality Rate of ALD in Korea Between 2000 and 2009
Item	2000	2009	Changes
MR: mortality rate per 100,000 populations. Statistically significant levels were set at P < 0.05 and *P < 0.01.
Nationwide
Mortality rate	1,403	2.98	3,588	7.21	+4.23**
Gender
Male	1,334	5.64	3,245	13.16	+7.52**
Female	69	0.31	343	1.42	+1.11**
Total	1,403		3,588
P-value	< 0.01		< 0.01
Age
20 - 29	12	0.28	6	0.15	0.13
30 - 39	152	3.49	198	4.76	+1.27**
40 - 49	468	13.26	1,076	31.53	+18.27**
50 - 59	369	16.97	1,230	56.01	+39.04**
60 - 69	259	17.89	721	41.20	+23.31**
> 70	143	20.31	357	27.29	+6.98**
Total	1,403		2,588
P-value	< 0.01		< 0.01

Table 2. Tends in the Mortality Rate of ALD in Korea Between 2000 and 2009

Item

2000

2009

Changes

Cases

MR: mortality rate per 100,000 populations. Statistically significant levels were set at *P < 0.05 and **P < 0.01.

Nationwide

Mortality rate

1,403

2.98

3,588

7.21

+4.23**

Gender

Male

1,334

5.64

3,245

13.16

+7.52**

Female

0.31

343

1.42

+1.11**

Total

1,403

3,588

P-value

< 0.01

Age

20 - 29

0.28

0.15

0.13

30 - 39

152

3.49

198

4.76

+1.27**

40 - 49

468

13.26

1,076

31.53

+18.27**

50 - 59

369

16.97

1,230

56.01

+39.04**

60 - 69

259

17.89

721

41.20

+23.31**

> 70

143

20.31

357

27.29

+6.98**

Total

1,403

2,588

P-value

< 0.01

**Table 3.** Trends in Epidemiological Aspects of the Case-Fatalities With Alcohol Liver Disease (ALD) in Korea Between 2000 and 2009
Item	2000	2009	Changes
95% CI: confidence interval of 95%. Mist: Mistresses, Stud: Students. Statistically significant levels were set at P < 0.05 and *P < 0.01.
Gender
Male	1,334	95.1 (94.0 - 96.2)	3,245	90.4 (89.4 - 91.4)	-4.7**
Female	69	4.9 (3.8 - 6.0)	343	10.5 (9.5 - 11.5)	+5.6**
Total	1,403		3,588
P-value	< 0.01		< 0.01
Age distribution
20 - 39	164	11.7 (10.0 - 13.4)	204	5.7 (4.9 - 6.5)	-6.0*
40 - 59	837	59.7 (57.1 - 62.3)	2,306	64.3 (63.0 - 65.6)	+4.6**
> 60	402	28.6 (26.3 - 28.9)	1,078	30.0 (28.8 - 31.2)	+1.4**
Total	1,403		3,588
P-value	< 0.01		< 0.01
Occupation
White-collar jobs	167	11.9 (10.2 - 13.6)	408	11.4 (10.4 - 12.4)	-0.5
Blue-collar jobs	159	11.3 (9.6 - 13.0)	279	7.8 (6.9 - 8.7)	-3.5**
Farmer and fishery	282	20.1 (18.0 - 22.2)	409	11.4 (10.4 - 12.4)	-8.7**
Mist/Stud/jobless	780	55.6 (53.0 - 58.2)	2,398	66.8 (65.3 - 68.3)	+11.2**
The other jobs	15	1.1 (0.6 - 1.6)	94	2.6 (2.1 - 3.1)	+1.5**
Total	1,403		3,588
P-value	< 0.01		< 0.01

Table 3. Trends in Epidemiological Aspects of the Case-Fatalities With Alcohol Liver Disease (ALD) in Korea Between 2000 and 2009

Item

2000

2009

Changes

Cases

% (95% CI)

Cases

% (95% CI)

95% CI: confidence interval of 95%. Mist: Mistresses, Stud: Students. Statistically significant levels were set at *P < 0.05 and **P < 0.01.

Gender

Male

1,334

95.1 (94.0 - 96.2)

3,245

90.4 (89.4 - 91.4)

-4.7**

Female

4.9 (3.8 - 6.0)

343

10.5 (9.5 - 11.5)

+5.6**

Total

1,403

3,588

P-value

< 0.01

Age distribution

20 - 39

164

11.7 (10.0 - 13.4)

204

5.7 (4.9 - 6.5)

-6.0*

40 - 59

837

59.7 (57.1 - 62.3)

2,306

64.3 (63.0 - 65.6)

+4.6**

> 60

402

28.6 (26.3 - 28.9)

1,078

30.0 (28.8 - 31.2)

+1.4**

Total

1,403

3,588

P-value

< 0.01

Occupation

White-collar jobs

167

11.9 (10.2 - 13.6)

408

11.4 (10.4 - 12.4)

-0.5

Blue-collar jobs

159

11.3 (9.6 - 13.0)

279

7.8 (6.9 - 8.7)

-3.5**

Farmer and fishery

282

20.1 (18.0 - 22.2)

409

11.4 (10.4 - 12.4)

-8.7**

Mist/Stud/jobless

780

55.6 (53.0 - 58.2)

2,398

66.8 (65.3 - 68.3)

+11.2**

The other jobs

1.1 (0.6 - 1.6)

2.6 (2.1 - 3.1)

+1.5**

Total

1,403

3,588

P-value

< 0.01

**Table 4.** Trends in the Case-Fatalities and Mortality Rate of the Most Prevalent Types of Alcoholic Liver Disease by ICD in Korea Between 2000 and 2009
Item	2000	2009
MR: mortality rate per 100,000 populations. 95% CI: confidence interval of 95%. Statistically significant levels were set at P < 0.05 and *P < 0.01.
Distribution of ALD	Cases	% (95% CI)	Cases	% (95% CI)	Changes
K70.0: Fatty liver	25	1.8 (1.1 - 2.5)	12	0.3 (0.1 - 05)	-1.5*
K70.1: Hepatitis	149	10.6 (9.0 - 12.2)	215	6.1 (5.3 - 6.9)	-4.5**
K70.2: Fibro./sclerosis	607	43.3 (40.7 - 45.9)	120	3.3 (2.7 - 3.9)	-40.0**
K70.3: Cirrhosis	229	16.3 (14.3 - 18.3)	2,803	78.1 (76.7 - 79.5)	+61.8**
K70.4: Hepatic failure	17	1.2 (0.6 - 1.8)	58	1.6 (1.2 - 2.0)	0.4
K70.9: Unspecified	376	26.8 (24.5 - 29.1)	380	10.6 (9.6 - 11.6)	-16.2**
Total	1,403	100.0	3,588	100.0
P-value	< 0.01		< 0.01
Mortality rate	Cases	MR (95% CI)	Cases	MR (95% CI)	Changes
K70.0: Fatty liver	25	0.05 (0.02 - 0.08)	12	0.02 (0.01 - 0.03)	-0.03
K70.1: Hepatitis	149	0.32 (0.27 - 0.37)	215	0.43 (0.40 - 0.46)	+0.11*
K70.2: Fibro./sclerosis	607	1.30 (1.20 - 1.40)	120	0.24 (022 - 0.26)	+1.06**
K70.3: Cirrhosis	229	0.49 (0.43 - 0.86)	2,803	5.63 (5.52 - 5.74)	+5.14**
K70.4: Hepatic failure	17	0.04 (0.02 - 0.06)	58	0.12 (0.11 - 0.14)	0.08
K70.9: Unspecified	376	0.78 (0.70 - 0.86)	380	0.76 (0.72 - 0.80)	-0.02
Total	1,403	2.98	3,588	7.21
P-value	< 0.01		< 0.01

Table 4. Trends in the Case-Fatalities and Mortality Rate of the Most Prevalent Types of Alcoholic Liver Disease by ICD in Korea Between 2000 and 2009

Item

2000

2009

MR: mortality rate per 100,000 populations. 95% CI: confidence interval of 95%. Statistically significant levels were set at *P < 0.05 and **P < 0.01.

Distribution of ALD

Cases

% (95% CI)

Cases

% (95% CI)

Changes

K70.0: Fatty liver

1.8 (1.1 - 2.5)

0.3 (0.1 - 05)

-1.5*

K70.1: Hepatitis

149

10.6 (9.0 - 12.2)

215

6.1 (5.3 - 6.9)

-4.5**

K70.2: Fibro./sclerosis

607

43.3 (40.7 - 45.9)

120

3.3 (2.7 - 3.9)

-40.0**

K70.3: Cirrhosis

229

16.3 (14.3 - 18.3)

2,803

78.1 (76.7 - 79.5)

+61.8**

K70.4: Hepatic failure

1.2 (0.6 - 1.8)

1.6 (1.2 - 2.0)

0.4

K70.9: Unspecified

376

26.8 (24.5 - 29.1)

380

10.6 (9.6 - 11.6)

-16.2**

Total

1,403

100.0

3,588

100.0

P-value

< 0.01

Mortality rate

Cases

MR (95% CI)

Cases

MR (95% CI)

Changes

K70.0: Fatty liver

0.05 (0.02 - 0.08)

0.02 (0.01 - 0.03)

-0.03

K70.1: Hepatitis

149

0.32 (0.27 - 0.37)

215

0.43 (0.40 - 0.46)

+0.11*

K70.2: Fibro./sclerosis

607

1.30 (1.20 - 1.40)

120

0.24 (022 - 0.26)

+1.06**

K70.3: Cirrhosis

229

0.49 (0.43 - 0.86)

2,803

5.63 (5.52 - 5.74)

+5.14**

K70.4: Hepatic failure

0.04 (0.02 - 0.06)

0.12 (0.11 - 0.14)

0.08

K70.9: Unspecified

376

0.78 (0.70 - 0.86)

380

0.76 (0.72 - 0.80)

-0.02

Total

1,403

2.98

3,588

7.21

P-value

< 0.01