J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 4, Number 6, December 2012, pages 385-392

Switching to Pitavastatin in Statin-Treated Low HDL-C Patients Further Improves the Lipid Profile and Attenuates Minute Myocardial Damage

Figure

Figure 1. Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) (A), high-sensitive troponin T (hsTnT) (B), and high-sensitve C-reactive protein (hsCRP) (C) levels before and at six months after the replacement of the previous statin with 2 mg/day pitavastatin.

Tables

**Table 1.** Baseline Patient Characteristics
HT: hypertension, DM: diabetes mellitus; CAD: coronary artery disease; CCB: calcium channel blocker; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker, BB: beta blocker.
Age, years	66.4 ± 7.8
Gender (%)	Male, 15 (75%); Female, 5 (25%)
Body mass index	24.8 ± 3.4
Current smokers (%)	5 (25%)
Co-morbidity (%)	HT 11 (55%), DM 6 (30%), CAD 8 (40%)
Statin before the enrollment (%)	Pravastatin 10 (50%); Simvastatin 1 (5%); Atorvastatin 8 (40%); Rosuvastatin 1 (5%)
Co-administration (%)	CCB, 13 (65%); ACEI and/or ARB, 12 (60%); BB, 8 (40%); Diuretics, 3 (15%), Anti-thrombotics, 10 (50%)

**Table 2.** Serial Changes in the Laboratory Data of the Overall Subjects
	Baseline	3 months	6 months
TC: total cholesterol; HDL-C: high density lipoprotein cholesterol; TG: triglycerides; LDL-C: low density lipoprotein cholesterol; L/H: LDL-C/HDL-C; AST: asparatate aminotransferase; ALT: alanine aminotransferase; CPK: creatine phosphokinase; NT-pro BNP: N-terminal pro-brain natriuretic peptide; hsTnT: high sensitive troponin T; hsCRP: high sensitive C-reactive protein. ^: P < 0.05 vs baseline, ^*: P < 0.01 vs baseline
TC (mg/dL)	176 ± 29	160 ± 27*	167 ± 24
HDL-C (mg/dL)	37 ± 3	40 ± 5*	41 ± 6*
TG (mg/dL)	192 ± 80	169 ± 78	187 ± 69
LDL-C (mg/dL)	100 ± 28	86 ± 22*	89 ± 24*
L/H ratio	2.68 ± 0.67	2.17 ± 0.64**	2.18 ± 0.68*
Creatinine (mg/dL)	0.89 ± 0.20	0.88 ± 0.21	0.90 ± 0.22
AST (IU/L)	24 ± 9	26 ± 9	26 ± 12
ALT (IU/L)	26 ± 13	27 ± 11	27 ± 12
CPK (IU/L)	125 ± 173	102 ± 54	91 ± 38
NT-proBNP (pg/mL)	181 ± 272		257 ± 440
hsTnT (ng/mL)	0.009 ± 0.011		0.007 ± 0.009
hsCRP (ng/mL)	2,994 ± 6,572		884 ± 653