Ear Involvement in Inflammatory Bowel Disease: A Review of the Literature

Fotios S. Fousekis, Maria Saridi, Eleni Albani, Fady Daniel, Konstantinos H. Katsanos, Ioannis G. Kastanioudakis, Dimitrios K. Christodoulou

Abstract


Inflammatory bowel disease (IBD) is a multisystemic disease. The ear is a rare but recognized site of extraintestinal manifestations of IBD. In external ear, the more common manifestations of IBD are pyoderma gangrenosum, metastatic Crohn’s disease and relapsing polychondritis and the treatment includes corticosteroids and anti-TNF agents. Sensorineural hearing loss (SNHL) is the most common ear disease in IBD and especially in patients with ulcerative colitis. In most cases of IBD patients with SNHL, the hearing loss is attributable to autoimmune inner ear disease (AIED). Diagnosis of AIED is based on clinical presentation, the demonstration of a progressive sensorineural hearing loss in periodic audiological tests, a response to immunosuppressive drugs and exclusion of other causes of SNHL. The only diagnostic test that is available for clinical use is the Otoblot test (Western blot for antibodies against 68 kD protein-inner ear antigens). Initial therapy is usually steroids, with a step up to anti-TNF-a therapy and cochlear implantations with failure of treatment. Furthermore, Cogan’s syndrome, a chronic disease characterized by deafness, vertigo keratitis and aortitis, has been associated with IBD and mainly with Crohn’s disease.




J Clin Med Res. 2018;10(8):609-614
doi: https://doi.org/10.14740/jocmr3465w

Keywords


Crohn’s disease; Ulcerative colitis; Autoimmune inner ear disease; Sensorineural hearing loss; Extraintestinal manifestations

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